Photo Flash: First Look at Neve Campbell on GREY'S ANATOMY

Check out a first look at Neve Campbell as one of Derek Shepherd's sisters in the upcoming GREY'S ANATOMY episode, "Love Turns you Upside Down," below! The episode will air Dec. 6 on ABC.

"Love Turns You Upside Down" - The new batch of interns find themselves involved in all the drama at Seattle Grace: Meredith asks Heather to go above and beyond to help fix Derek's hand; Cristina starts a healthy competition between Stephanie and Leah, which inadvertently leads to a medical emergency for Cristina's patient; Alex sees Jo in a new light as they work to save a baby's life, and April teaches Shane a valuable lesson during "lumps and bumps" duty, on "Grey's Anatomy," THURSDAY, DECEMBER 6 (9:00-10:02 p.m., ET) on the ABC Television Network.

Photos Courtesy of ABC

Neve Campbell

TINA MAJORINO, Neve Campbell

Ellen Pompeo

Ellen Pompeo, Sara Ramirez

Sandra Oh, Ellen Pompeo