VIDEO: Sneak Peek - Neve Campbell Debuts on ABC's GREY'S ANATOMY

Related: GREY'S ANATOMY, ABC, Previews & Teasers

Neve Campbell makes her GREY'S ANATOMY debut tonight on ABC in the role of 'Liz' one of Derek's sisters. In the episode titled "Love Turns You Upside Down", the new batch of interns find themselves involved in all the drama at Seattle Grace: Meredith asks Heather to go above and beyond to help fix Derek's hand; Cristina starts a healthy competition between Stephanie and Leah, which inadvertently leads to a medical emergency for Cristina's patient; Alex sees Jo in a new light as they work to save a baby's life, and April teaches Shane a valuable lesson during "lumps and bumps" duty. The episode airs (9:00-10:02 p.m., ET) on the ABC Television Network.

"Grey's Anatomy" stars Ellen Pompeo as MerEdith Grey, Patrick Dempsey as Derek Shepherd, Sandra Oh as Cristina Yang, Justin Chambers as Alex Karev, Chandra Wilson as Miranda Bailey, James Pickens, Jr. as Richard Webber, Sara Ramirez as Callie Torres, Eric Dane as Mark Sloan, Kevin McKidd as Owen Hunt, Jessica Capshaw as Arizona Robbins, Jesse Williams as Jackson Avery and Sarah Drew as April Kepner.

Guest cast for "Love Turns You Upside Down" includes Neve Campbell as Liz Sheperd, CAMILLA LUDDINGTON as Jo, Gaius Charles as Shane, Tima Majorino as Heather, JERRIKA HINTON as Stephanie, TESSA FERRER as Leah, Graham Sibley as Noah, Laila Ayad as Laura, Julie Wittner as Mrs. Crossley, Sean Donnellan as Mr. Crossley and Alyssa Preston as Kimmy's Mama.

The episode was written by Stacy McKee and directed by Mark Jackson.